Introducing individual mutations to mtDNA is challenging due to the large number of mitochondria within each cell. Instead, the researchers used a leukemia mouse model with a defective genetic ...

Kura and Kyowa used the announcement to confirm that they are on track to file a new drug approval application with the FDA ...

ASXL1 mutations are very common in patients with ... genomes and harmful DNA repeats found in chronic monomyelocytic leukemia patients with mutated ASXL1. Dong says the LJI team is investigating ...

St. Jude researchers reveal that moderate levels of mitochondrial DNA mutations boost leukemia growth by increasing metabolic plasticity, while high mutation levels shut down tumor development. They ...

Scientists from Flinders University in Australia have made a surprising discovery about a recently identified type of genetic material called circular RNAs. Their research suggests that these ...

Kuro Oncology and partner Kyowa Kirin are on track for an NDA submission for ziftomenib in the second quarter of this year.

Given the frequent identification of somatic mutations in genes encoding regulators of transcription in leukemia and lymphoma, the Abdel-Wahab is especially focused on understanding the functional ...

Venetoclax, a selective Bcl-2 inhibitor, has proven effective in chronic lymphocytic leukemia (CLL), but genetic mutations or ...