General Hospital ’s longest recurring actor and portrayer of matriarch Monica Quartermaine, Leslie Charleson, has died at 79. Since the show’s executive producer Frank Valentini shared the news on Sunday, fans and fellow cast members have shared their reactions to the significant loss.

Leslie Charleson, who played cardiologist Monica Quartermaine on "General Hospital" for five decades, has died, according to the soap opera's producer. She was 79.

Colleagues are remembering the soap opera star for her "quick wit" and presence on set. She died after a long illness.

Leslie Charleson, who played popular character Dr. Monica Quartermaine for almost 50 years on “General Hospital,” has died, the program’s executive producer announced on Sunday.

Longtime "General Hospital" star Leslie Charleson has died at 79, the show's executive producer Frank Valentini shared in a statement.

Leslie Charleson, whose Dr. Monica Quartermaine was the longest-tenured character on “General Hospital,” has died. She was 79. Charleson died of complications from a long illness, said ABC News, which broadcasts the long-running soap opera.

Soap opera icon Leslie Charleson, best known as Monica Quartermaine on "General Hospital," died Sunday morning after a long illness. She was 79.

Wally Kurth joined General Hospital in 1991 as Ned Ashton, a member of the Quartermaine family — so Ned enjoyed a close relationship with his aunt, Monica Quartermaine, played by Leslie Charleson, who passed away on January 12,

Leslie Charleson, perhaps best known for playing Dr. Monica Quartermaine on TV’s “General Hospital” for five decades, has passed away. She was 79. News of Charleson’s death was announced Sunday by Frank Valentini,

Leslie Charleson, best known for her role of Monica Quartermaine on General Hospital, has died. She was 79 years old. The soap opera star’s death was announced in a post on the General Hospital official Instagram account on Sunday.

ABC Photo Archives/Disney General Entertainment Content via Getty Images Leslie Charleson, who played Dr. Monica Quartermaine on “General Hospital” for nearly half a century, has died ...