The immune systems of cancer patients are highly disrupted, with those who have a higher number of immune cells in their blood having a better survival rate, finds a new study that uses a pioneering ...

Pancreatic cancer (PC) is the worst prognosis cancer globally, with just 13% of patients who are diagnosed with PC surviving for 5 years or more after initial diagnosis. Early detection of PC is the ...

Mitochondrial stress disrupts insulin production in diabetes, but reversing the damage may restore β-cell function.

Phase I clinical trials are the first step in testing a new treatment or combination of treatments. These trials often ...

Researchers determine a complex immune infiltrate pattern based on a newly constructed immune map developed using pancreatic ...

The distinct population of endothelial cells that line blood vessels in the insulin-producing "islets" of the human pancreas ...

Pancreatic cancer patients may benefit from future precision treatments as a new study shows how some tumors may potentially ...

UTRECHT, The Netherlands and CAMBRIDGE, Mass., Feb. 05, 2025 (GLOBE NEWSWIRE) -- Merus N.V. (Nasdaq: MRUS) (Merus, the Company, we, or our), a ...

Objective Innate immunity plays important roles in pancreatic ductal adenocarcinoma (PDAC), as non-T-cell-enriched tumour. Neutrophils are major players in innate immune system. Here, we aimed to ...

Objective Pancreatic ductal adenocarcinoma (PDAC ... which hijacked low metastatic cancer cells for metastasis. The interleukin (IL)-33–ST2–TAMs axis was the primary driver for upregulating CXCL3 that ...

The efficacy of CD19-CAR T-cell therapy is presumably based on deep tissue depletion of B cells; however, such effect has not been proven in humans in vivo. Methods Sequential ultrasound-guided ...