Key Takeaways GSK Plc's U.S.-listed shares surged Wednesday after the pharmaceutical firm boosted its long-term outlook and launched a $2.5 billion stock buyback on the back of optimism about sales of its new drugs.

GSK Plc plans to buy back £2 billion ($2.5 billion) of shares as it raised its long-term growth outlook on optimism around the drug pipeline.

Uber's fourth-quarter operating profit rose 18% to $770 million but fell well short of the $1.2 billion forecast by analysts, hitting shares.

Ride-hailing firm Uber reported strong fourth-quarter revenue, but the outlook for bookings and Ebitda both came in light.

Uber tumbled early Wednesday after Q4 earnings and sales beat but its bookings target came in light. Mark Cuban didn't become a billionaire by playing it safe, but he didn't get there by throwing money around like confetti at a parade.