Cells maintain a continuous free pool of ubiquitin that can be conjugated onto target proteins to mark them for degradation by the proteasome. Now, in Cell, Finley and colleagues show that the ...

The 26S proteasome contains a 20S core particle ... recognition as well as DUBs and ATPases to deconjugate ubiquitin chains and unfold degradation substrates, respectively. The role of ubiquitin ...

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart -- an important process for maintaining heart health.

A disrupted protein degradation process in heart muscle cells can lead to a range of severe heart diseases. In the case of ...

C-terminal amidation is a PTM that involves the addition of an amid group to the C-terminus of a peptide or protein. Currently there is no direct evidence to suggest that C-terminal amidation of ...

Booster Therapeutics has announced its inception, backed by a $15m investment, to develop a new class of proteasome activator ...

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart – an important process for maintaining heart health.

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Nobel Laureate Aaron Ciechanover emphasizes the importance of democracy in science for progress and innovation.

C4 Therapeutics, Inc. engages in the development of targeted protein degradation science to develop ... clearance from the cell through the natural ubiquitin and proteasome system.