Nobel Laureate Aaron Ciechanover emphasizes the importance of democracy in science for progress and innovation.

The 26S proteasome contains a 20S core particle ... recognition as well as DUBs and ATPases to deconjugate ubiquitin chains and unfold degradation substrates, respectively. The role of ubiquitin ...

The physiological roles of DUBs are as pervasive as the ubiquitin–proteasome system itself ... that promotes the degradation of many key cell cycle regulators. USP44 activity is crucial for ...

Akribion Therapeutics emerges from stealth with €8 million in seed funding to develop a novel cancer RNA-guided approach ...

The ubiquitin-proteasome system (UPS) is a non-lysosomal proteolytic pathway involved in numerous normal functions of the nervous system, modulation of neurotransmitter release, synaptic plasticity, ...

A disrupted protein degradation process in heart muscle cells can lead to a range of severe heart diseases. In the case of ...

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart -- an important process for maintaining heart health.

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart – an important process for maintaining heart health.

Increland has identified proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to an interleukin-1 receptor-associated kinase 4 (IRAK-4) ...

Ubiquitination is a PTM characterized by the covalent binding of ubiquitin (Ub) molecule to a specific target protein. This essential PTM primarily determines protein stability by marking the target ...