Nobel Laureate Aaron Ciechanover emphasizes the importance of democracy in science for progress and innovation.

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart -- an important process for maintaining heart health.

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart – an important process for maintaining heart health.

A disrupted protein degradation process in heart muscle cells can lead to a range of severe heart diseases. In the case of ...

Increland has identified proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to an interleukin-1 receptor-associated kinase 4 (IRAK-4) ...

C-terminal amidation is a PTM that involves the addition of an amid group to the C-terminus of a peptide or protein. Currently there is no direct evidence to suggest that C-terminal amidation of ...

New research uncovers how declining protein clearance mechanisms with age lead to Alzheimer’s, Parkinson’s, and other ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Liquid Sunlight Alliance, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, United States Chemical Sciences Division, Lawrence Berkeley National Laboratory, 1 ...

CHIP mutation prompts the upregulation of cAMP, increasing PKAc and further competitively inhibiting the ubiquitin-mediated degradation of PDE9A. Pharmacological inhibition of PDE9A- or AAV-mediated ...