“The Substance” co-stars Demi Moore and Margaret Qualley butted heads as they played off their characters in the body horror film in a playfully contentious bit at this year’s Golden Globes on Sunday.

Last year, the Golden Globes were hosted by comedian Jo Koy, who tanked after delivering a series of crude jokes, including teasing that 2023’s “Oppenheimer” was based on a Pulitzer Prize-winning book ...