In recent years, several important advances have been made in our understanding of the pathways that lead to cell dysfunction and death in Parkinson's disease (PD) and Huntington's disease ... and non ...

Huntington’s disease symptoms are linked to expanding DNA repeats (CAG) that become toxic in brain cells over time The "ticking DNA clock" accelerates after 80 repeats, killing neurons within ...

The team found that although functions such as movement, thinking or behavior remained normal for a long time before the onset of symptoms in Huntington's disease, subtle changes to the brain were ...

The team found that although functions such as movement, thinking or behavior remained normal for a long time before the onset of symptoms in Huntington's disease, subtle changes to the brain were ...

A study published in Nature Medicine reveals subtle neurodegenerative changes in people with Huntington’s disease gene expansion up to 20 years before symptoms appear. Using advanced imaging, blood ...

Subtle signs of neurodegeneration can be detected in blood, cerebrospinal fluid (CSF), and through neuroimaging, up to two decades before motor symptoms in Huntington’s disease (HD) present ...

The cumulative death of many such cells leads to the symptoms of Huntington's disease. The study offers a potential explanation as to why candidate Huntington's drugs that aim to reduce expression ...

A new UCLA Health study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease ...

For many people, the symptoms of Huntington's disease will not begin to show for decades. The genetic disorder is incurable but it is not uncommon for sufferers to reach middle-age before the ...

A hallmark of Huntington’s disease is that the number of CAG repeats a person has determines when in life symptoms start, if ever. Forty or more generally result in the arrival of Huntington ...