Nobel Laureate Aaron Ciechanover emphasizes the importance of democracy in science for progress and innovation.

C-terminal amidation is a PTM that involves the addition of an amid group to the C-terminus of a peptide or protein. Currently there is no direct evidence to suggest that C-terminal amidation of ...

The 26S proteasome contains a 20S core particle ... recognition as well as DUBs and ATPases to deconjugate ubiquitin chains and unfold degradation substrates, respectively. The role of ubiquitin ...

The physiological roles of DUBs are as pervasive as the ubiquitin–proteasome system itself ... that promotes the degradation of many key cell cycle regulators. USP44 activity is crucial for ...

Akribion Therapeutics emerges from stealth with €8 million in seed funding to develop a novel cancer RNA-guided approach ...

The ubiquitin-proteasome system (UPS) is a non-lysosomal proteolytic pathway involved in numerous normal functions of the nervous system, modulation of neurotransmitter release, synaptic plasticity, ...

The proteasome-part of the internal cellular machinery-breaks down specific cellular proteins. Ubiquitin is a protein that attaches to other proteins to earmark them for degradation by helping the ...

Specifically, hSPAR fulfills its functions by two coordinate pathways: On one hand, hSPAR stabilizes the protein level of P27KIP1 in the cytoplasm by blocking TRIM21-mediated ubiquitin-proteasome ...

Delve into the increasingly dynamic landscape of ALS treatment development with thirteen companies advancing candidates in ...

Pain marks the second therapeutic area for Cullgen’s lead protein degrader CG001419SAN DIEGO, Jan. 22, 2025 (GLOBE NEWSWIRE) -- Cullgen Inc. (“Cullgen”), a privately-held, clinical-stage ...

This domain exhibits ubiquitin-binding properties and auto ... proteins generally function as cofactors that link the proteasome to ubiquitinated substrates, playing crucial roles in protein ...