Nobel Laureate Aaron Ciechanover emphasizes the importance of democracy in science for progress and innovation.

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart -- an important process for maintaining heart health.

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart – an important process for maintaining heart health.

A disrupted protein degradation process in heart muscle cells can lead to a range of severe heart diseases. In the case of ...

Increland has identified proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to an interleukin-1 receptor-associated kinase 4 (IRAK-4) ...

C-terminal amidation is a PTM that involves the addition of an amid group to the C-terminus of a peptide or protein. Currently there is no direct evidence to suggest that C-terminal amidation of ...

New research uncovers how declining protein clearance mechanisms with age lead to Alzheimer’s, Parkinson’s, and other ...

CHIP mutation prompts the upregulation of cAMP, increasing PKAc and further competitively inhibiting the ubiquitin-mediated degradation of PDE9A. Pharmacological inhibition of PDE9A- or AAV-mediated ...

Fluorescence intensity measurements were used to monitor the cleavage of a ubiquitin-rhodamine substrate. All activity assays were performed in black 384-well plates in assay buffer (20 mM Tris–HCl, ...

Abstract: In converter applications, the body diode SiC MOSFET is often repurposed as freewheeling diode to reduce cost and save space, it potentially leads the device to bipolar degradation. This ...